Journal article
The relationship between body composition and structural changes at the knee
PA Berry, AE Wluka, ML Davies-Tuck, Y Wang, BJ Strauss, JB Dixon, J Proietto, G Jones, FM Cicuttini
Rheumatology | Published : 2010
Abstract
Objective: Obesity is an important risk factor for knee OA. Evidence suggests that fat and muscle have differential effects on the pathogenesis of disease. The aim of this study was to examine the relationship between body composition and knee structure, including knee cartilage volume, defects and bone marrow lesions (BMLs). Methods: A total of 153 subjects aged 25-60 years, 81% females, were recruited across a range of BMI (18-55 kg/m2) for a study examining the relationship between obesity and musculoskeletal disease. MRI was performed of the dominant knee. Cartilage volume, defects and BMLs were measured using validated methods. Body composition was measured using dual X-ray absorptiomet..
View full abstractGrants
Awarded by Monash University
Funding Acknowledgements
This study was supported by the National Health Medical Research Council (384233), the Shepherd Foundation and Monash University.